The WT1 gene (chromosome 11) is required for the morphogenesis of the urogenital system and represents a regulation gene for the transcription of the SRY.

The gene expression of the SOX9 gene (chromosome 17), which in the mouse is found in the genital ridge of both sexes and in the supporting cells (Sertoli), plays a role in the activation of the AMH gene (antimüllerian hormone). The mutation with a functional failure of a single copy of the SOX9 gene leads to a reversal of the gender of a male individual (46,XY)

The SF1 gene (chromosome 9) is expressed in the gonad anlagen of both sexes, activates the expression of the gene for the synthesis of steroids.

The DAX1 gene (chromosome X), which is also expressed in the genital ridges, hinders the activation of SF1. An excessive expression of DAX1 hinders a differentiation of the testes.

The gene coding for AMH (antimüllerian hormone; chromosome 19) is responsible for the atrophy of the paramesonephric duct (Müller).